Immunomodulation in hepatocellular cancer

Local immunomodulation for cancer therapy

In murine models of cancer, we have achieved efficient systemic activation of tumor-specific T cells by the local administration of a CTLA4-blocking antibody at low doses. Using a slow-release formulation, we could drastically lower the serum levels of the antibody, hence decreasing adverse effects and the risk of autoimmune reactions, without losing systemic efficacy.

Immunomodulation of Breast Cancer via Tumor Antigen

Advances in molecular immunology have greatly improved our understanding of the function of the immune system, particularly in regards to immune-cancer interactions. We now see cancer as a chronic inflammatory disease where immune cells may actually function to enhance rather than inhibit tumor growth (1). If one could reverse the chronic inflammatory state of cancer and, instead, create the ty...

Hepatocellular Carcinoma in Sheep

The miR-383-LDHA axis regulates cell proliferation, invasion and glycolysis in hepatocellular cancer

Objective(s): To explore the correlation between expression patterns and functions of miR-383 and LDHA in hepatocellular cancer (HCC). Materials and Methods: We detected the expression of miR-383 and LDHA in 30 HCC tissues and their matched adjacent normal tissues using qRT-PCR. Then we performed MTT assay, foci formation assay, transwell migration assay, glucose uptake assay and lactate produc...

Hepatocellular carcinoma in a sheep

At necropsy of a five-year-old sheep, a pear shaped, lobular yellow-brownish mass measuring about 12 ×15 × 20 cm was found to involve the right hepatic lobe. Microscopic examination revealed two trabecularand solid patterns of neoplastic hepatocytes. In solid pattern, there were numerous tumoral giant cells thatcontain one or more large hyperchromatic bizarre-shaped nuclei scattered among clust...